| Alabama | Richard C. ShelbyR | 1,335,104 votes · +586,395 over Ron Crumpton |
| Alaska | Lisa MurkowskiR | 138,149 votes · +47,324 over Joe Miller |
| Arizona | John McCainR | 1,359,267 votes · +328,022 over Ann Kirkpatrick |
| Arkansas | John BoozmanR | 661,984 votes · +261,382 over Conner Eldridge |
| California | Kamala HarrisD | 7,542,753 votes · +2,841,336 over Loretta Sanchez |
| Colorado | Michael F. BennetD | 1,370,710 votes · +155,392 over Darryl Glenn |
| Connecticut | Richard BlumenthalD | 1,008,714 votes · +456,093 over Dan Carter |
| Florida | Marco RubioR | 4,835,191 votes · +713,103 over Patrick Murphy |
| Georgia | Johnny IsaksonR | 2,135,806 votes · +536,080 over Jim Barksdale |
| Hawaii | Brian SchatzD | 306,604 votes · +213,951 over John Carroll |
| Idaho | Mike CrapoR | 449,017 votes · +260,768 over Jerry Sturgill |
| Illinois | Tammy DuckworthD | 3,012,940 votes · +828,248 over Mark Steven Kirk |
| Indiana | Todd C. YoungR | 1,423,991 votes · +265,044 over Evan Bayh |
| Iowa | Charles E. GrassleyR | 926,007 votes · +376,547 over Patty Judge |
| Kansas | Jerry MoranR | 732,376 votes · +352,636 over Patrick Wiesner |
| Kentucky | Rand PaulR | 1,090,177 votes · +276,931 over Jim Gray |
| Louisiana | John KennedyR | 536,191 votes · +188,375 over Foster Campbell |
| Maryland | Chris van HollenD | 1,659,907 votes · +687,350 over Kathy Szeliga |
| Missouri | Roy BluntR | 1,378,458 votes · +78,258 over Jason Kander |
| Nevada | Catherine Cortez MastoD | 521,994 votes · +26,915 over Joseph J. Heck |
| New Hampshire | Maggie HassanD | 354,649 votes · +1,017 over Kelly Ayotte |
| New York | Charles E. SchumerW | 5,221,949 votes · +3,212,596 over Wendy Long |
| North Carolina | Richard BurrR | 2,395,376 votes · +267,211 over Deborah K. Ross |
| North Dakota | John HoevenR | 268,788 votes · +210,672 over Eliot Glassheim |
| Ohio | Rob PortmanR | 3,118,567 votes · +1,121,659 over Ted Strickland |
| Oklahoma | James LankfordR | 980,892 votes · +624,981 over Mike Workman |
| Oregon | Ron WydenD | 1,105,119 votes · +454,013 over Mark Callahan |
| Pennsylvania | Patrick J. ToomeyR | 2,951,702 votes · +86,690 over Katie McGinty |
| South Carolina | Tim ScottR | 1,241,609 votes · +484,587 over Thomas Dixon |
| South Dakota | John R. ThuneR | 265,516 votes · +161,376 over Jay Williams |
| Utah | Mike LeeR | 760,220 votes · +458,362 over Misty K. Snow |
| Vermont | Patrick J. LeahyD | 192,243 votes · +88,606 over Scott Milne |
| Washington | Patty MurrayD | 1,913,979 votes · +584,641 over Chris Vance |
| Wisconsin | Ron JohnsonR | 1,479,471 votes · +99,136 over Russell D. Feingold |