| Arizona | Jeff FlakeR | 1,104,457 votes · +67,915 over Richard Carmona |
| California | Dianne FeinsteinD | 7,864,624 votes · +3,150,737 over Elizabeth Emken |
| Connecticut | Christopher S. MurphyD | 828,761 votes · +177,672 over Linda E. McMahon |
| Delaware | Thomas R. CarperD | 265,415 votes · +149,715 over Kevin Wade |
| Florida | Bill NelsonD | 4,523,451 votes · +1,065,184 over Connie Mack |
| Hawaii | Mazie K. HironoD | 269,489 votes · +108,495 over Linda Lingle |
| Indiana | Joe DonnellyD | 1,281,181 votes · +147,560 over Richard E. Mourdock |
| Maine | Angus S. King Jr.I | 370,580 votes · +155,181 over Charles E. Summers Jr. |
| Maryland | Benjamin L. CardinD | 1,474,028 votes · +780,737 over Daniel John Bongino |
| Massachusetts | Elizabeth Ann WarrenD | 1,696,346 votes · +238,298 over Scott P. Brown |
| Michigan | Debbie StabenowD | 2,735,826 votes · +968,440 over Pete Hoekstra |
| Minnesota | Amy KlobucharD | 1,854,595 votes · +986,621 over Kurt Bills |
| Mississippi | Roger F. WickerR | 709,626 votes · +206,159 over Albert N. Gore Jr. |
| Missouri | Claire McCaskillD | 1,494,125 votes · +427,966 over W. Todd Akin |
| Montana | Jon TesterD | 236,123 votes · +18,072 over Denny Rehberg |
| Nebraska | Deb FischerR | 455,593 votes · +122,614 over J. Robert Kerrey |
| Nevada | Dean HellerR | 457,656 votes · +11,576 over Shelley Berkley |
| New Jersey | Robert MenendezD | 1,987,680 votes · +658,146 over Joe Kyrillos |
| New Mexico | Martin HeinrichD | 395,717 votes · +44,457 over Heather A. Wilson |
| New York | Kirsten E. GillibrandW | 4,808,878 votes · +3,053,412 over Wendy Long |
| North Dakota | Heidi HeitkampD | 161,337 votes · +2,936 over Rick Berg |
| Ohio | Sherrod BrownD | 2,762,690 votes · +326,978 over Josh Mandel |
| Pennsylvania | Robert P. Casey Jr.D | 3,021,364 votes · +512,232 over Tom Smith |
| Rhode Island | Sheldon WhitehouseD | 271,034 votes · +124,812 over Benjamin Barrett Hinckley III |
| Tennessee | Bob CorkerR | 1,506,443 votes · +800,561 over Mark E. Clayton |
| Texas | Ted CruzR | 4,440,137 votes · +1,245,210 over Paul Sadler |
| Utah | Orrin G. HatchR | 657,608 votes · +355,735 over Scott N. Howell |
| Vermont | Bernie SandersI | 207,848 votes · +134,950 over John MacGovern |
| Virginia | Tim KaineD | 2,010,067 votes · +224,525 over George F. Allen |
| Washington | Maria CantwellD | 1,855,493 votes · +641,569 over Michael Baumgartner |
| West Virginia | Joe Manchin IIID | 399,898 votes · +159,111 over John R. Raese |
| Wisconsin | Tammy BaldwinD | 1,547,104 votes · +166,978 over Tommy G. Thompson |
| Wyoming | John BarrassoR | 185,250 votes · +132,231 over Tim Chesnut |